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). In Abl kinase domain, the amino acid residues at the corresponding positions are Gln and Val, respectively, providing no scope for 4 to covalently modify them, unlike a cysteine (36). Although the aromatic mustard motif is such that the alkylation ability would be low or absent, confirmation was required to exclude covalent modification as a possible mode of inhibition.
Тема Светлая Темная Высокая контрастность
Среднесписочная количество нет данных Специальный налоговый режим
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LNK headquarters in Vilnius LNK is a commercial television channel operating in Lithuania. It is a free-to-air TV channel targeted at a Lithuanian audience and primarily broadcasts local entertainment, dubbed movies, lifestyle shows, bäçķľn aĺ and news.
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The interaction between the kinase domain and 4 was studied by measuring the kinetics of change in intrinsic tryptophan fluorescence of the kinase domain using a fluorimeter fitted with stop-flow attachment at room temperature. In all the experiments, λex and λem were fixed at 290 and 350 nm, respectively.
Стэн Ли, Джеймс Шеймус, Джон Турман, Майкл Франс, Джек Кирби